Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs
نویسندگان
چکیده
منابع مشابه
Foster, Neil and Richards, Luke and Higgins, John and Kanellos, Theo and Barrow, Paul (2016) Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged
We show that oral inoculation of 5 day old conventional piglets with a rough. attenuated S. Infantis 1326/28Ф (serogroup C1), 24h prior to oral challenge with S. Typhimurium 4/74 (serogroup B), resulted in significant weight gain (~10%) measured at 14 days post-weaning (38 days of age). Two days after challenge the S. Typhimurium induced stunting and, in some cases loss, of villi but this was p...
متن کاملOral Somatic Transgene Vaccination Using Attenuated S. typhimurium
An attenuated strain of S. typhimurium has been used as a vehicle for oral genetic immunization. Eukaryotic expression vectors containing truncated genes of ActA and listeriolysin--two virulence factors of Listeria monocytogenes--have been used to transform S. typhimurium aroA. Multiple or even single oral immunizations with such transformants induced excellent cellular and humoral responses. I...
متن کاملThe molecular investigation of widespread Salmonella serovars, S. typhimurium and S. enteritidis, involved in salmonellosis of cattle and sheep in farms around Tehran, Iran
Salmonellosis as an important zoonotic disease that causes food born poisoning in human through animalproducts and is considered as a worldwide public health hazard. Widespread studies have been conducted ondifferent aspects of incidence, treatment and control of salmonelosis all over the world. The aim of this studywas to evaluate the occurrence of widespread Salmonella serovars, S. typhimuriu...
متن کاملSimultaneous oral administration of Salmonella Infantis and S. Typhimurium in chicks
BACKGROUND To confirm the hypothesis that Salmonella enterica subspecies enterica serovar (S.) Infantis has higher basic reproductive rates in chicks compared with other Salmonella serovars, 1-day-old specific-pathogen-free chicks (n = 8) were challenged simultaneously with S. Infantis and S. Typhimurium per os. Challenged chicks (Group A) were then housed with non-infected chicks (Group B, n =...
متن کاملSalmonella Typhimurium lacking the Znuabc transporter is attenuated and immunogenic in pigs.
Meat contamination by Salmonella spp. is emerging as a major cause of human enteric infections in industrialized countries. The attempts to reduce human cases of salmonellosis encompass pre- and post-harvest interventions. In this context, vaccination of pigs may represent an effective instrument in eliminating/reducing Salmonella burden through the food chain. We have previously demonstrated t...
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ژورنال
عنوان ژورنال: Research in Veterinary Science
سال: 2016
ISSN: 0034-5288
DOI: 10.1016/j.rvsc.2015.12.013